Bioprinting
3D printing represents a family of additive manufacturing processes that construct solid models through layer-by-layer deposition of building materials. The process has been used for freeform fabrication of various medical models and device prototypes. In our lab, 3D printing processes are used to produce traceable tissue-simulating phantoms for calibration and standardization of biomedical optical devices. Biomedical optical devices play an important role in diagnosis and treatment of many diseases. To ensure accurate calibrate and reliable performance of medical devices, it is necessary to establish traceable standards for calibration and validation before clinical applications. However, such a traceable calibration standard is not available for many medical optical devices. We aim at 3D printing of solid phantoms that simulate tissue physical, optical and pathophysiologic properties as a traceable standard for calibration and validation of spectral optical devices. The “Healthy China 2030” plan emphasizes the importance of accelerating the transformation and upgrading of medical devices, improving the quality standard system, and enhancing quality control technology. The proposed tissue-simulating phantoms are expected to establish traceable digital phantom standards for scientific research and regulatory approval of biomedical optical devices.
Projects:
- Industrial sponsored on 3D optical skin mimetic design technology, 2021-12 to 2022-12, JY2260080124.
- Key R&D Project, Ministry of Science and Technology of the People's Republic of China, Research and Preparation System of Tissue Blood Oxygen Bionanomorphs System Development, 2021-12 to 2024-11, 2021YFC2401402.
Participating researchers:
Representative Publications:
- Shuwei Shen; Haili Wang; Yingjie Qu; Kuiming Huang; Guangli Liu; Zexin Chen; Canzhen Ma; Pengfei Shao; Jin Hong; Paul Lemaillet; Erbao Dong; Ronald X Xu ; Simulating orientation and polarization characteristics of dense fibrous tissue by electrostatic spinning of polymeric fibers, Biomedical optics expres, 2019, 10(2): 571-583
- Shuwei Shen; Haili Wang; Yue Xue; Li Yuan; Ximing Zhou; Zuhua Zhao; Erbao Dong; Bin Liu; Wendong Liu,; Barrett Cromeens; Brent Adler; Gail Besner; Ronald X. Xu ; Freeform fabrication of tissue-simulating phantom for potential use of surgical planning in conjoined twins separationsurgery, Scientific reports, 2017, 7(11048): 1-11
- Canzhen Ma#; Shuwei Shen#; Guangli Liu; Siyue Guo; Buyun Guo; Jialuo Li; Kuiming Huang; Yidan Zheng; Pengfei Shao; Erbao Dong; Jiaru Chu; Ronald X. Xu ; Multimodal 3D Printing of Phantoms to Simulate Biological Tissue, 2020, 155
- Chen, Hongyu; Liu, Guangli; Zhang, Shulin; Shen, Shuwei; Luo, Yuhao; Li, Jialuo; Roberts, Cynthia J; Sun, Mingzhai; Xu, Ronald X; "Fundus-simulating phantom for calibration of retinal vessel oximetry devices, Applied Optics, 2019, 3877-3885
- Lv, Xiang; Chen, Hongyu; Liu, Guangli; Shen, Shuwei; Wu, Qiang; Hu, Chuanzhen; Li, Jialuo; Dong, Erbao; Xu, Ronald X; "Design of a portable phantom device to simulate tissue oxygenation and blood perfusion,Applied Optics, 2018 :3938-3946
- Liu, Guangli; Huang, Kuiming; Jia, Qiumin; Liu, Songde; Shen, Shuwei; Li, Jialuo; Dong, Erbao; Lemaillet, Paul; Allen, David W; Xu, Ronald X; "Fabrication of a multilayer tissue-mimicking phantom with tunable optical properties to simulate vascular oxygenation and perfusion for optical imaging technology, Applied optics, 2018, 6772-6780
- Liu, Guangli; Wu, Qiang; Dwivedi, Pankaj; Hu, Chuanzhen; Zhu, Zhiqiang; Shen, Shuwei; Chu, Jiaru; Zhao, Gang; Si, Ting; Xu, Ronald; "Hemoglobin-laden microcapsules for simulating oxygen dynamics of biological tissue,ACS Biomaterials Science & Engineering,2018, 3177-3184
Patents:
- 邵鹏飞; 申书伟; 马灿臻; 董二宝 ; 一种用于多功能生理参数检测仪器的校准装置和方法, 2020-3-25, 中国, CN202010218290.2 (发明专利)
- 马灿臻; 邵鹏飞; 董二宝; 申书伟 ; 生物光学仿体三维打印生产线和方法, 2020-5-12, 中国,CN201811505318.X (发明专利)
- 马东奇; 申书伟; 孙明斋; 徐晓嵘 ; 一种三维眼球仿体及其制备方法与应用, 2022-08-19, 中国,CN202210998045.7 (发明专利)